منابع مشابه
Developmental Commitment in a Bacterium
We investigated developmental commitment during sporulation in Bacillus subtilis. Sporulation is initiated by nutrient limitation and involves division of the developing cell into two progeny, the forespore and the mother cell, with different fates. Differentiation becomes irreversible following division when neither the forespore nor the mother cell can resume growth when provided with nutrien...
متن کاملDevelopmental commitment in Dictyostelium discoideum.
Upon starvation, Dictyostelium discoideum cells halt cell proliferation, aggregate into multicellular organisms, form migrating slugs, and undergo morphogenesis into fruiting bodies while differentiating into dormant spores and dead stalk cells. At almost any developmental stage cells can be forced to dedifferentiate when they are dispersed and diluted into nutrient broth. However, migrating sl...
متن کاملDevelopmental and dyadic perspectives on commitment in adult romantic relationships.
We tested hypotheses concerning the developmental roots of becoming the "weak-link" (less committed) partner in adult romantic relationships and the associations between partners' absolute and relative levels of commitment and dyadic outcomes. We examined 78 target 20- to 21-year-olds who were involved in a romantic relationship and who had been studied since birth. As predicted, people who rec...
متن کاملDevelopmental fate and lineage commitment of singled mouse blastomeres.
The inside-outside model has been invoked to explain cell-fate specification of the pre-implantation mammalian embryo. Here, we investigate whether cell-cell interaction can influence the fate specification of embryonic blastomeres by sequentially separating the blastomeres in two-cell stage mouse embryos and continuing separation after each cell division throughout pre-implantation development...
متن کاملMolecular control of irreversible bistability during trypanosome developmental commitment
The life cycle of Trypanosoma brucei involves developmental transitions that allow survival, proliferation, and transmission of these parasites. One of these, the differentiation of growth-arrested stumpy forms in the mammalian blood into insect-stage procyclic forms, can be induced synchronously in vitro with cis-aconitate. Here, we show that this transition is an irreversible bistable switch,...
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ژورنال
عنوان ژورنال: Cell
سال: 2005
ISSN: 0092-8674
DOI: 10.1016/j.cell.2005.02.032